Deuterium labeling Information

Deuterium labeling

The exchange of hydrogen with its isotope deuterium has a wide range of useful applications. The underlying principle is that while replacement of hydrogen with deuterium minimally changes the basic functions of the compound, it gives rise to clear kinetic isotope effect (KIE).

The applications include study of reaction mechanisms, isotope dilution analysis, and structural analysis of biological components. In recent years, deuterated drugs designed to slow down metabolism have been developed and tested in clinical trials. The incorporation of deuterium is also known in the field of optical and electronic devices, where it is used to enhance optical properties and durability.